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2 article(s) from Vilaivan, Tirayut

Fluorogenic PNA probes

Tirayut Vilaivan

Beilstein J. Org. Chem. 2018, 14, 253–281, doi:10.3762/bjoc.14.17

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Graphical Abstract

Figure 1: The design of classical DNA molecular beacons.

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Figure 2: Structures of DNA and selected PNA systems.

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Figure 3: Various binding modes of PNA to double stranded DNA including triplex formation, triplex invasion, ...

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Figure 4: The design and working principle of the PNA beacons according to (A) Ortiz et al. [41] and (B) Armitage...

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Figure 5: The design of "stemless" PNA beacons.

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Figure 6: The applications of PNA openers to facilitate the binding of PNA beacons to double stranded DNA [40,47].

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Figure 7: The working principle of snap-to-it probes that employed metal chelation to bring the dyes in close...

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Figure 8: Examples of pre-formed dye-labeled PNA monomers and functionalizable PNA monomers.

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Figure 9: Dual-labeled PNA beacons with end-stacking or intercalating quencher.

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Figure 10: The working principle of hybrid PNA-peptide beacons for detection of (A) proteins [80] and (B) protease...

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Figure 11: The working principle of binary probes.

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Figure 12: The working principle of nucleic acid templated fluorogenic reactions leading to a (A) ligated prod...

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Figure 13: Catalytic cycles in fluorogenic nucleic acid templated reactions [90].

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Figure 14: The working principle of strand displacement probes.

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Figure 15: (A) Examples of CPP successfully used with labeled PNA probes. (B) The use of single-labeled PNA pr...

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Figure 16: The concept of PNA–GO platform for DNA/RNA sensing.

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Figure 17: Single-labeled fluorogenic PNA probes.

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Figure 18: Examples of environment sensitive fluorescent labels that have been incorporated into PNA probes as...

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Figure 19: The mechanism of fluorescence change in TO dye.

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Figure 20: Fluorescent nucleobases capable of hydrogen bonding that have been incorporated into PNA probes.

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Figure 21: Comparison of the designs of the (A) light-up PNA probe and (B) FIT PNA probe.

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Figure 22: The structures of TO and its analogues that have successfully been used in FIT PNA probes.

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Figure 23: The working principle of dual-labeled FIT PNA probes [222,223].

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Review

Published 29 Jan 2018

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Synthesis and optical properties of pyrrolidinyl peptide nucleic acid carrying a clicked Nile red label

Nattawut Yotapan,
Chayan Charoenpakdee,
Pawinee Wathanathavorn,
Boonsong Ditmangklo,
Hans-Achim Wagenknecht and
Tirayut Vilaivan

Beilstein J. Org. Chem. 2014, 10, 2166–2174, doi:10.3762/bjoc.10.224

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Graphical Abstract

Scheme 1: Synthesis of propargylated Nile red 1.

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Scheme 2: Synthesis of azidobutyl- and Nile red-modified acpcPNA.

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Figure 1: MALDI–TOF mass spectra of the crude 10mer acpcPNA before (top) (calcd m/z 3688.0), and after functi...

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Figure 2: Normalized absorption (---) and fluorescence (––) spectra of (a) propargyl Nile red 1 and (b) Nile ...

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Figure 3: (a) Normalized absorption (---) and fluorescence (––) spectra and (b) fluorescence spectra of Nile ...

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Supp Info

Full Research Paper

Published 11 Sep 2014

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